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KMID : 0390219990100020244
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Journal of Clinical Otolaryngology, Head and Neck Surgery
1999 Volume.10 No. 2 p.244 ~ p.249
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Nasopharyngeal Carcinoma : The Result of Radiotherapy after High-Dose Induction Chemotherapy with Cisplatin +5-Flurouracil and Analysis of Prognostic Factors
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노환중/Hwan Jung Roh
박현민/이병주/오일준/고의경/왕수건/전경명/Hyun Min Park/Byung Joo Lee/Il Joon Oh/Eui Kyung Goh/Soo Geun Wang/Kyong Myong Chon
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Abstract
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Background and Objectives : Nasopharyngeal carcinoma shows relatively poor
prognosis due to the difficulty of early diagnosis, the tendency of metastasis, and high
recurrence rate. The purpose of this study is to evaluate the survival rate of induction
chemtherapy with cispatin+5-Fu, and to analyze the prognostic factors of nasopharyngeal
carcinoma.
Material and Methods : The materials were forty nasopharyngeal carcinoma patients
who treated with 3 courses of induction chemotherapy with Cisplatin (100 ㎎
/㎡) and 5-Fu (1000㎎/㎡) and thereafter radiotherapy in Pusan National University
Hospital from May, 1987 through December, 1996. We performed retrospective analysis
about presumed prognostic factors such as sex, age, histopathologic types according
to WHO classification, presence of metastatic cervical lymph node. We also compare
AJCC and Ho staging systems to estimate the preferred relationship with prognosis.
Results : The overall survival rates of 3-year and 5-year were 66.3% and 53.6%,
respectively. Cervical lymph nodal metastasis had significant correlation with survival
rate (p<0.05). However, there was no statistical significance of sex, age and
histopathologic types with survival rate (p>0.05). AJCC and Ho classification also didn't
correlate with prognosis statistically in all stages.
Conclusion : High dose induction chemotherapy with Cisplatin and 5-Fu and
radiotherapy shows better 3-year and 5-year survival than other treatment modalities as
reported in others. The prognosis of nasopharngeal carcinoma have significant correlation
with cervical lymph node metastasis at the time ol diagnosis. We suggest the necessity
of new staging system for the prediction of the prognosis of nasopharyngeal carcinoma.
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KEYWORD
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